LAYOUT OF THE 2019 WORKSHOP

Sun 10th March

DAY 1 Monday March 11th

08:30 Arrive at Congress Centre for a prompt start at...:

08:40 Mike Taussig (Cambridge): Welcome and Introduction

Session 1: Protein and Cell Atlas (Chair: Mike Taussig)

08:50 KEYNOTE: Mathias Uhlen (Stockholm): Mapping the human blood and brain using omics
09:10 Kerstin Meyer (Cambridge): Towards a human cell atlas: mapping the maternal fetal interface
09:30 Bernd Bodenmiller (Zürich): Highly multiplexed imaging of tissues with subcellular resolution by imaging mass cytometry
09:50 Gabriele Gut (Zürich): Multiplexed protein maps link subcellular organization to cellular states
10:05 Fridtjof Lund-Johansen (Oslo): Antibody array analysis meets mass spectrometry
10:20 Dean Clift (Cambridge): Trim-Away: A new technology for direct degradation of endogenous cellular proteins
10:35 Niv Papo (BeerSheva): Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

11:00 Coffee break

Session 2: Making antibodies I (Chair: John McCafferty)

11:30 John McCafferty (Iontas): Mammalian display: Antibody discovery, affinity maturation and developability screening in IgG format
11:50 Thomas Schirrmann (Yumab): YUMAB - bridging innovation to drug development
12:05 Michael Fiebig (Absolute Antibody): From murine bispecifics to rabbit-shark fusions: New opportunities and challenges
for classic (and unusual) research reagents through protein engineering
12:20 Peter McPherson (Montreal): Implementation of an antibody characterization process: Application to major neurological disease genes
12:40 Susanne Gräslund (Stockholm): Open-access biological probes for target validation
Discussion

13:00 Lunch & poster viewing

Session 3: Antibody Design and Therapeutics (Chair: Simon Goodman)

14:30 Simon Goodman (Darmstadt): In search of the perfect beast: looking for therapeutic antibodies?
14:45 Sarel Fleishman (Weizmann): Computational design of new and improved antibodies and binding pairs
15:05 Dario Neri (Zürich): Antibody-cytokine fusion proteins for the therapy of cancer and of chronic inflammation
15:25 Peter Ellmark (Alligator Bio): Engineering of functional and developable TNFRSF bispecific antibodies
15:40 Sophia Hober (Stockholm): The development of small protein domains for biotechnical and medical use

16:00 Tea Break

Session 4: Antibody Diagnostic Tools (Chair: Ulf Landegren)

16:30 KEYNOTE: Ulf Landegren (Uppsala): Tools for high-performance protein analyses
16:50 Carl Borrebaeck (Lund): So you think you have a proteomic test for diagnosing cancer?
17:10 Nebojsa Janjic (SomaLogic): Nucleic acid ligands with base modification for enhanced coverage of the proteome
17:30 Martin Lundberg (Olink): Fit for purpose analytical studies with Proximity Extension Assay (PEA)
17:45 Brian Kay (Chicago): Generating reagents for sandwich assay through phage display
18:00 Jochen Schwenk (Stockholm): Insights into integrating the human plasma proteome

18:30 Poster Flash session (Chair: Jochen Schwenk)

19:00 Reception drinks & Poster viewing

20:00 Dinner at Congress Centre

DAY 2 Tuesday March 12^th

Session 5: Nanobodies and DARPins (Chair: Cecile Vincke, Brussels)

08:30 KEYNOTE: Jan Steyaert (Brussels): From Nanobodies to Megabodies for applications in cryo-EM
08:50 Hidde Ploegh (Harvard): Tracking immune responses non-invasively by positron emission tomography using small antibody fragments (VHHs or nanobodies) as imaging agents
09:10 Ulrich Rothbauer (Tübingen): Nano- and Chromobodies: How to visualize and quantify proteins in living cells
09:30 Markus Seeger (Zürich): Protein selections in the absence of a physical genotype-phenotype linkage
09:50 Jim Trimmer (U.C. Davis): Recombinant antibodies and nanobodies for studying and manipulating neuronal function
10:10 Sophie Hernot (Brussels): Nanobodies as tracers for molecular imaging and intra-operative image-guidance
10:25 Birgit Dreier (Zurich): Binders for Challenging Tasks - A High-Throughput DARPin Selection and Validation Pipeline
10:40 Discussion

11:00 Lunch, break for skiing and other activities

15:30 Tea and poster viewing

Session 6: Binder validation and standardisation (Chair: Matt Baker, ThermoFisher)

16:00 Patrik Wollberg (Atlas Antibodies): Advances in Enhanced Validation ensuring reliable research results
16:15 Alejandra Solache (Abcam): Best-in-class antibody generation and validation: improving reproducibility and influencing health outcomes
16:30 Anita Bandrowski (SciCrunch): RRIDs: Antibody identification and authentication
16:40 Industry Podium Discussion, Moderators: Matt Baker (Thermo Fisher) and Andy Chalmers (Bath): How can companies create standards for antibodies? Panel members from ThermoFisher, Atlas Antibodies, Abcam, Cell Signaling Technology and others.

19:30 Dinner at Rossmoos

DAY 3 Wednesday March 13^th

Session 7: Academia meets industry (Chair: Andreas Plückthun)

08:30 KEYNOTE: Andreas Plückthun (Zürich): Different generations of binding proteins
08:50 Larry Gold (SomaLogic): Large-scale proteomics for improved medicine and health
09:10 Discussion

Session 8: Arrays (Chair: Peter Nilsson, Stockholm)

09:30 Jörg Hoheisel (Heidelberg): Proteomic analyses in tumour biology: toward mechanistic insights, personalised diagnostics, and novel therapy options
09:50 Anna Månberg (Stockholm): Protein profiling reveals correlations to CSF tau levels in preclinical Alzheimer’s disease
10:05 Scott Paschke (CDI): High-throughput discovery of actionable serologic biomarkers and ultra-specific monoclonal antibodies
10:20 Volker Stadler (PepperPrint): Antibody validation and antigen discovery by combining protein and peptide microarrays
10:35 Ann Holmberg (Qlucore): Instant visualisation and analysis of proteomics data

11:00 Lunch, poster viewing, break for skiing and other activities

15:30 Tea and poster viewing

Session 9: Making Antibodies II (Chair: Jörg Hoheisel, Heidelberg)

16:00 Andrew Bradbury (Specifica): The power of next generation sequencing in antibody library generation and selection
16:20 Michael Weiner (Abcam): Directed Targeting of Antibody Discovery
16:35 Maren Bleckmann (Braunschweig): Antibodies with affinity switches
16:50 Jürgen Schmitz (Miltenyi): REAfinity and REAlease antibody technology for enhanced reproducibility and reversible cell labeling
17:05 Tara Hiltke (NIH): NCI Ab Characterization Program: Affinity Reagent Resources for Human Proteome Detection

Tea Break

Session 10: Short talks (Chair: Oda Stoevesandt)

17:30 Victor Greiff (Oslo): Deciphering the complexity of antibody binding using machine learning
17:45 Michael Hust (Braunschweig): Fighting pathogens and toxins with human and human-like recombinant antibodies
18:00 Andreas Hougaard Laustsen (TU Danmark): Recombinant snakebite antivenoms based on oligoclonal human antibodies
18:15 Christian Moritz (St. Etienne): Characterizing the repertoire of targeted autoantigens of autoimmune neuropathies
18:25 Sina Bondza (Ridgeview): Characterizing antibody interactions with living cells in real-time
18:35 Christophe Ritzenthaler (Strasbourg): Nanobody-aided functionalization of virus-like particles

18:45 Mike Taussig: Winding up

19:30 Buffet Dinner and Party with Stars 'n' Bars

THE PROGRAMME FOR 2024 IS IN PREPARATION