LAYOUT OF THE 2019 WORKSHOP (PRELIMINARY)
Sun 10th March: Registration, Pre-workshop Reception and Buffet Dinner at Congress Centre
DAY 1 Monday March 11th
Mike Taussig (Cambridge): Welcome and Introduction
Session 1: Protein and Cell Atlas (Chair: Mike Taussig)
- KEYNOTE: Mathias Uhlen (Stockholm): Mapping the human blood and brain using omics
- Kerstin Meyer (Cambridge): Towards a human cell atlas: mapping the maternal fetal interface
- Bernd Bodenmiller (Zürich): Highly multiplexed imaging of tissues with subcellular resolution by imaging mass cytometry
- Gabriele Gut (Zürich): Multiplexed protein maps link subcellular organization to cellular states
- Fridtjof Lund-Johansen (Oslo): Antibody array analysis meets mass spectrometry
- Dean Clift (Cambridge): Trim-Away: A new technology for direct degradation of endogenous cellular proteins
- Niv Papo (BeerSheva): Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
Coffee break
Session 2: Making antibodies I (Chair: John McCafferty)
- John McCafferty (Iontas): Mammalian display: Antibody discovery, affinity maturation and developability screening in IgG format
- Thomas Schirrmann (Yumab): YUMAB - bridging innovation to drug development
- Michael Fiebig (Absolute Antibody): From murine bispecifics to rabbit-shark fusions: New opportunities and challenges
for classic (and unusual) research reagents through protein engineering - Peter McPherson (Montreal): Implementation of an antibody characterization process: Application to major neurological disease genes
- Susanne Gräslund (Stockholm): Open-access biological probes for target validation
- Discussion
Lunch & poster viewing
Session 3: Antibody Design and Therapeutics (Chair: Simon Goodman)
- Simon Goodman (Darmstadt): In search of the perfect beast: looking for therapeutic antibodies?
- Sarel Fleishman (Weizmann): Computational design of new and improved antibodies and binding pairs
- Dario Neri (Zürich): Antibody-cytokine fusion proteins for the therapy of cancer and of chronic inflammation
- Peter Ellmark (Alligator Bio): Engineering of functional and developable TNFRSF bispecific antibodies
- Sophia Hober (Stockholm): The development of small protein domains for biotechnical and medical use
Tea Break
Session 4: Antibody Diagnostic Tools (Chair: Ulf Landegren)
- KEYNOTE: Ulf Landegren (Uppsala): Tools for high-performance protein analyses
- Carl Borrebaeck (Lund): So you think you have a proteomic test for diagnosing cancer?
- Nebojsa Janjic (SomaLogic): Nucleic acid ligands with base modification for enhanced coverage of the proteome
- Martin Lundberg (Olink): Fit for purpose analytical studies with Proximity Extension Assay (PEA)
- Brian Kay (Chicago): Generating reagents for sandwich assay through phage display
- Jochen Schwenk (Stockholm): Insights into integrating the human plasma proteome
Poster Flash session (Chair: Jochen Schwenk)
Reception drinks & Poster viewing
Dinner at Congress Centre
DAY 2 Tuesday March 12th
Session 5: Nanobodies and DARPins (Chair: Cecile Vincke, Brussels)
- KEYNOTE: Jan Steyaert (Brussels): From Nanobodies to Megabodies for applications in cryo-EM
- Hidde Ploegh (Harvard): Tracking immune responses non-invasively by positron emission tomography using small antibody fragments (VHHs or nanobodies) as imaging agents
- Ulrich Rothbauer (Tübingen): Nano- and Chromobodies: How to visualize and quantify proteins in living cells
- Markus Seeger (Zürich): Protein selections in the absence of a physical genotype-phenotype linkage
- Jim Trimmer (U.C. Davis): Recombinant antibodies and nanobodies for studying and manipulating neuronal function
- Sophie Hernot (Brussels): Nanobodies as tracers for molecular imaging and intra-operative image-guidance
- Birgit Dreier (Zurich): Binders for Challenging Tasks - A High-Throughput DARPin Selection and Validation Pipeline
Lunch, break for skiing and other activities
Session 6: Binder validation and standardisation (Chair: Matt Baker, ThermoFisher)
- Patrik Wollberg (Atlas Antibodies): Advances in Enhanced Validation ensuring reliable research results
- Alejandra Solache (Abcam): Best-in-class antibody generation and validation: improving reproducibility and influencing health outcomes
- Industry Podium Discussion, Moderators: Matt Baker (Thermo Fisher) and Andy Chalmers (Bath): How can companies create standards for antibodies? Panel members from ThermoFisher, Atlas Antibodies, Abcam, Cell Signaling Technology and others.
Dinner at Rossmoos
DAY 3 Wednesday March 13th
Session 7: Academia meets industry (Chair: Andreas Plückthun)
- KEYNOTE: Andreas Plückthun (Zürich): Different generations of binding proteins
- Larry Gold (SomaLogic): Large-scale proteomics for improved medicine and health
Session 8: Arrays (Chair: Peter Nilsson, Stockholm)
- Jörg Hoheisel (Heidelberg): Proteomic analyses in tumour biology: toward mechanistic insights, personalised diagnostics, and novel therapy options
- Anna Månberg (Stockholm): Protein profiling reveals correlations to CSF tau levels in preclinical Alzheimer’s disease
- Oda Stoevesandt (Cambridge Protein Arrays): Protein arrays for validation and discovery
- Scott Paschke (CDI): High-throughput discovery of actionable serologic biomarkers and ultra-specific monoclonal antibodies
- Volker Stadler (PepperPrint): Antibody validation and antigen discovery by combining protein and peptide microarrays
- Ann Holmberg (Qlucore): Instant visualisation and analysis of proteomics data
Lunch, break for skiing and other activities
Session 9: Making Antibodies II (Chair: Jörg Hoheisel, Heidelberg)
- Andrew Bradbury (Specifica): The power of next generation sequencing in antibody library generation and selection
- Michael Weiner (Abcam): Directed Targeting of Antibody Discovery
- Stefan Dübel (Braunschweig): A universal switch module to regulate antibody affinity
- Jürgen Schmitz (Miltenyi): REAfinity and REAlease antibody technology for enhanced reproducibility and reversible cell labeling
- Victor Greiff (Oslo): Deciphering the complexity of antibody binding using machine learning
- Michael Hust (Braunschweig): Fighting pathogens and toxins with human and human-like recombinant antibodies
- Andreas Laustsen (Copenhagen): Recombinant snakebite antivenoms based on oligoclonal human antibodies
Tea Break
Session 10: Short talks (Chair: Mike Taussig)
Mike Taussig: Winding up
Buffet Dinner and Party with Stars 'n' Bars
The mid-day break on Tuesday and Wednesday (4 hours) will allow participants to make the most of the alpine location. Dinners are open to all participants, and on Wednesday evening, we finish with our traditional party for all. This inclusive approach ensures excellent networking opportunities. See our Gallery for impressions from previous years. Biographies of Speakers and Chairs received to date can be found here.